Retrospective analysis of renal prognosis in elderly coronary artery disease patients complicated with renal insufficiency.

Abstract

OBJECTIVE AND METHODS:

The aim of this study was to retrospectively analyze the renal prognosis of elderly coronary artery disease (CAD) patients complicated with renal insufficiency.

RESULTS:

A total of 307 patients were included. The mean follow-up period was 25±11months. The average age was 79±7 years. In the worsening renal function group, there were higher occurrence rate of heart failure and severe coronary artery stenosis, lower rate of percutaneous coronary intervention, lower medication rate of renin-angiotensin blocker, lower plasma albumin, magnesium and hemoglobulin level. There was no significant difference in the rate of worsening renal function or gastrointestinal bleeding between patients who took anti-platelet agents/statins and those without. Patients with reduced left ventricular ejective fraction had higher rate of worsening renal function, yet lower medication rate of renin-angiotensin blockers, lower plasma albumin and hemoglobulin level. Anemia, malnutrition and worsening cardiac function were risk factors of renal function deterioration and mortality.

CONCLUSIONS:

In the elderly coronary artery disease patients who had renal insufficiency, antiplatelet agents and statin have non-adverse effects on renal function; lower medication rate of renin-angiotensin blocker were found in patients with either worsening renal function or heart failure. Anemia, malnutrition and worsening cardiac function are risk factors of renal function deterioration and mortality.

• Authors: Jun Li, Fa-Hu Liu, Jing Guo, Ya-Fen Yu, Chun-Qing Li
• Journal: Aging (Aging (Albany NY)) Vol. 13 Issue 19 Pg. 22856-22866 (10 04 2021) ISSN: 1945-4589 [Electronic] United States
• PMID: 34606471 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Platelet Aggregation Inhibitors

Topics

• Aged
• Aged, 80 and over
• Coronary Disease (complications, drug therapy)
• Diabetes Mellitus
• Female
• Humans
• Hypertension (complications)
• Male
• Platelet Aggregation Inhibitors (therapeutic use)
• Renal Insufficiency (complications, pathology)
• Retrospective Studies
• Risk Factors