Follicular Helper T Cells in the Immunopathogenesis of SARS-CoV-2 Infection.
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| Abstract |
Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a serious infectious disease that has led to a global pandemic with high morbidity and mortality. High-affinity neutralizing antibody is important for controlling infection, which is closely regulated by follicular helper T (Tfh) cells. Tfh cells play a central role in promoting germinal center reactions and driving cognate B cell differentiation for antibody secretion. Available studies indicate a close relationship between virus-specific Tfh cell-mediated immunity and SARS-CoV-2 infection progression. Although several lines of evidence have suggested that Tfh cells contribute to the control of SARS-CoV-2 infection by eliciting neutralizing antibody productions, further studies are needed to elucidate Tfh-mediated effector mechanisms in anti-SARS-CoV-2 immunity. Here, we summarize the functional features and roles of virus-specific Tfh cells in the immunopathogenesis of SARS-CoV-2 infection and in COVID-19 vaccines, and highlight the potential of targeting Tfh cells as therapeutic strategy against SARS-CoV-2 infection.
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| Authors | Dawei Cui, Yuan Tang, Qi Jiang, Daixi Jiang, Yun Zhang, Yan Lv, Dandan Xu, Jian Wu, Jue Xie, Chengping Wen, Liwei Lu |
| Journal | Frontiers in immunology (Front Immunol) Vol. 12 Pg. 731100 ( 2021) ISSN: 1664-3224 [Electronic] Switzerland |
| PMID | 34603308 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review) |
| Copyright | Copyright © 2021 Cui, Tang, Jiang, Jiang, Zhang, Lv, Xu, Wu, Xie, Wen and Lu. |
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