Soluble LAG-3 and Toll-interacting protein: Novel upstream neuro-inflammatory markers in Parkinson's disease.

Abstract

INTRODUCTION:

There is some evidence regarding the role of LAG-3, TLR mediated neuroinflammation in PD.

METHODS:

sLAG-3, TOLLIP, NLRP3 levels were measured in PD and healthy controls.

RESULTS:

These markers were significantly higher in PD and were associated with progression.

CONCLUSION:

sLAG3 and TOLLIP are involved in the NLRP3 mediated inflammatory activation in PD.

• Authors: Akash Roy, Supriyo Choudhury, Rebecca Banerjee, Purba Basu, Hrishikesh Kumar
• Journal: Parkinsonism & related disorders (Parkinsonism Relat Disord) Vol. 91 Pg. 121-123 (10 2021) ISSN: 1873-5126 [Electronic] England
• PMID: 34601340 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Antigens, CD
• Biomarkers
• Intracellular Signaling Peptides and Proteins
• NLR Family, Pyrin Domain-Containing 3 Protein
• NLRP3 protein, human
• TOLLIP protein, human
• Lymphocyte Activation Gene 3 Protein
• Lag3 protein, human
• soluble LAG-3 protein, human

Topics

• Antigens, CD (blood)
• Biomarkers (blood)
• Case-Control Studies
• Female
• Humans
• Intracellular Signaling Peptides and Proteins (blood)
• Male
• NLR Family, Pyrin Domain-Containing 3 Protein (blood)
• Neuroinflammatory Diseases (genetics)
• Parkinson Disease (blood, genetics)
• Lymphocyte Activation Gene 3 Protein