Dysfunctional eating behavior in fibromyalgia and its association with serum biomarkers of brain plasticity (BDNF and S100B): an exploratory study.

Abstract

OBJECTIVE:

To assess disordered eating, hunger and satiety perceptions in women with fibromyalgia (FM) compared to healthy controls (HC) and their association with biomarkers of brain plasticity (brain-derived neurotrophic factor (BDNF) and S100 calcium-binding protein B (S100B)).

METHODS:

Cross-sectional exploratory study. The sample included FM (n = 20) and HC (n = 19), matched to age and waist perimeter. Dysfunctional eating was assessed through the Three Factor Eating Questionnaire and Eating Disorders Examination with a questionnaire. Hunger and satiety levels were rated by a Numerical Scale. Serum leptin, S100B and BDNF were analyzed.

RESULTS:

The MANCOVA analysis showed that the mean of Emotional Eating rates was 30.65% higher in FM compared to HC (p = 0.015). Eating, shape and weight concerns were 77.77%, 57.14% and 52.22% higher in FM (p = <0.001) compared to HC, respectively. Moreover, the FM group reported higher scores for feeling of hunger "[5.2 (±2.9) vs. 4.8 (±2.0); p = 0.042] and lower scores for satiety [7.0 (±1.7) vs. 8.3 (±1.0); p = 0.038]. In the FM group, serum BDNF was negatively associated with hunger (r = - 0.52; p = 0.02), while S100B was positively associated with hunger scores (r = 0.463; p = 0.004).

CONCLUSION:

The present findings support the hypothesis that the association between FM and obesity can be mediated by a hedonistic pathway. Further research is needed.

• Authors: Jéssica Lorenzzi Elkfury, Luciana C Antunes, Letícia Dal Moro Angoleri, Raquel Busanello Sipmann, Andressa de Souza, Iraci Lucena da Silva Torres, Wolnei Caumo
• Journal: Archives of endocrinology and metabolism (Arch Endocrinol Metab) Vol. 65 Issue 6 Pg. 713-722 (Nov 24 2021) ISSN: 2359-4292 [Electronic] Brazil
• PMID: 34591410 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Brain-Derived Neurotrophic Factor
• S100 Calcium Binding Protein beta Subunit
• S100B protein, human

Topics

• Biomarkers
• Brain-Derived Neurotrophic Factor
• Cross-Sectional Studies
• Feeding Behavior
• Female
• Fibromyalgia
• Humans
• Neuronal Plasticity
• S100 Calcium Binding Protein beta Subunit