Hepatitis B Vaccines.

Abstract

Hepatitis B is caused by the hepatitis B virus (HBV), which infects the liver and may lead to chronic liver disease, including cirrhosis and hepatocellular carcinoma. HBV represents a worldwide public health problem, causing major morbidity and mortality. Affordable, safe, and effective, hepatitis B vaccines are the best tools we have to control and prevent hepatitis B. In 2019, coverage of 3 doses of the hepatitis B vaccine reached 85% worldwide compared to around 30% in 2000. The effective implementation of hepatitis B vaccination programs has resulted in a substantial decrease in the HBV carrier rate and hepatitis B-related morbidity and mortality. This article summarizes the great triumphs of the hepatitis B vaccine, the first anticancer and virus-like-particle-based vaccine. In addition, existing unresolved issues and future perspectives on hepatitis B vaccination required for global prevention of HBV infection are discussed.

• Authors: Jade Pattyn, Greet Hendrickx, Alex Vorsters, Pierre Van Damme
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 224 Issue 12 Suppl 2 Pg. S343-S351 (09 30 2021) ISSN: 1537-6613 [Electronic] United States
• PMID: 34590138 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

Chemical References

• Hepatitis B Vaccines
• Hepatitis B e Antigens

Topics

• Hepatitis B (immunology, prevention & control)
• Hepatitis B Vaccines (adverse effects, therapeutic use)
• Hepatitis B e Antigens
• Hepatitis B virus (immunology)
• Humans
• Vaccination