History of bariatric surgery and COVID-19 outcomes in patients with type 2 diabetes: Results from the CORONADO study.

Abstract

OBJECTIVE:

This study assessed the impact of a history of metabolic and bariatric surgery (MBS) on the clinical outcomes in patients with type 2 diabetes (T2D) and severe obesity hospitalized for COVID-19.

METHODS:

In this post hoc analysis from the nationwide observational CORONADO (Coronavirus SARS-CoV2 and Diabetes Outcomes) study, patients with T2D and a history of MBS were matched with patients without MBS for age, sex, and BMI either at the time of MBS or on admission for COVID-19. The composite primary outcome (CPO) combined invasive mechanical ventilation and/or death within 7 and 28 days following admission.

RESULTS:

Out of 2,398 CORONADO participants, 20 had a history of MBS. When matching for BMI at the time of MBS and after adjustment for diabetes duration, the CPO occurred less frequently within 7 days (3 vs. 17 events, OR: 0.15 [0.01 to 0.94], p = 0.03) and 28 days (3 vs. 19 events, OR: 0.11 [0.01 to 0.71], p = 0.02) in patients with MBS (n = 16) vs. controls (n = 44). There was no difference in CPO rate between patients with MBS and controls when matching for BMI on admission.

CONCLUSIONS:

These data are reassuring regarding COVID-19 prognosis in patients with diabetes and a history of MBS compared with those without MBS.

• Authors: Claire Blanchard, Tanguy Perennec, Sarra Smati, Blandine Tramunt, Béatrice Guyomarch, Edith Bigot-Corbel, Lyse Bordier, Sophie Borot, Olivier Bourron, Cyrielle Caussy, Christine Coffin-Boutreux, Anne Dutour, Natacha Germain, Céline Gonfroy-Leymarie, Laurent Meyer, Gaëtan Prevost, Ronan Roussel, Dominique Seret-Bégué, Charles Thivolet, Bruno Vergès, Matthieu Pichelin, Pierre Gourdy, Samy Hadjadj, Matthieu Wargny, François Pattou, Bertrand Cariou, CORONADO investigators
• Journal: Obesity (Silver Spring, Md.) (Obesity (Silver Spring)) Vol. 30 Issue 3 Pg. 599-605 (03 2022) ISSN: 1930-739X [Electronic] United States
• PMID: 34586754 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 The Obesity Society.

Chemical References

• RNA, Viral

Topics

• Bariatric Surgery
• COVID-19
• Diabetes Mellitus, Type 2
• Humans
• RNA, Viral
• Retrospective Studies
• SARS-CoV-2