Abstract | PURPOSE: METHODS: A total of 30 adult Sprague-Dawley rats were used in this experimental study. The central cornea of the rats was cauterized chemically. The rats were randomly enrolled into three groups as follows: Group 1 received bevacizumab 1%, Group 2 received cyclosporine 0.1%, and Group 3 received isotonic saline twice a day for 28 days. Slit-lamp examination of all rats was performed at the 3rd and 28th day. The rats were then sacrificed, and the corneas were excised. The number of blood vessels, state of inflammation, and collagen formation were evaluated histopathologically in the corneal sections. RESULTS:
Corneal opacity and edema grades were significantly lower in Group 2 than in Group 3 (p=0.04 and 0.00, respectively). In the histopathological examination, Group 2 demonstrated significantly lesser number of blood vessels than Group 3 (p=0.001). Regarding collagen formation, Group 2 exhibited more regular collagen formation than Groups 1 and 3 (p=0.03). Inflammation grades were significantly lower in Groups 1 and 2 than in Group 3 (p=0.014 and 0.001, respectively). CONCLUSION:
|
Authors | Döndü Melek Ulusoy, Nisa Kahraman, Esra Balcıoğlu, Zeynep Duru |
Journal | Arquivos brasileiros de oftalmologia
(Arq Bras Oftalmol)
2022 Jan-Feb
Vol. 85
Issue 1
Pg. 19-24
ISSN: 1678-2925 [Electronic] Brazil |
PMID | 34586225
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Angiogenesis Inhibitors
- Cyclosporine
|
Topics |
- Angiogenesis Inhibitors
(therapeutic use)
- Animals
- Corneal Neovascularization
(drug therapy)
- Cyclosporine
(therapeutic use)
- Disease Models, Animal
- Rats
- Rats, Sprague-Dawley
|