Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating.

Abstract

INTRODUCTION:

This post hoc analysis evaluated the effect of prucalopride on abdominal bloating in participants with chronic idiopathic constipation (CIC) who had moderate to very severe bloating at baseline.

METHODS:

Data from 6 phase 3/4 studies of prucalopride in participants with CIC were pooled. Abdominal bloating was assessed weekly using a 5-point scale (0-4).

RESULTS:

The proportion of bloating responders (≥1-point improvement in abdominal bloating score at week 12) was higher in participants treated with prucalopride (62.1%) vs placebo (49.6%).

DISCUSSION:

The prucalopride arm had a higher proportion of bloating responders vs placebo in this study population.

• Authors: Kyle Staller, Jimmy Hinson, René Kerstens, William Spalding, Anthony Lembo
• Journal: The American journal of gastroenterology (Am J Gastroenterol) Vol. 117 Issue 1 Pg. 184-188 (01 01 2022) ISSN: 1572-0241 [Electronic] United States
• PMID: 34585675 (Publication Type: Clinical Trial, Phase III, Clinical Trial, Phase IV, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.

Chemical References

• Benzofurans
• Laxatives
• prucalopride

Topics

• Abdominal Pain (diagnosis, drug therapy, etiology)
• Aged
• Benzofurans (therapeutic use)
• Chronic Disease
• Constipation (complications, diagnosis, drug therapy)
• Double-Blind Method
• Female
• Humans
• Laxatives (therapeutic use)
• Male
• Pain Measurement
• Severity of Illness Index
• Treatment Outcome