Involvement of epithelia-derived exosomes in chronic respiratory diseases.

Abstract

Exosomes are tiny membrane lipid bilayer vesicles (φ40-100 nm) formed by the fusion of multivesicular bodies with plasma membrane, which are released extracellular by exocytosis. As natural nanocarriers, exosomes contain a variety of signal substances of the mother cell: nucleic acids, proteins and lipids, etc., which always play a vital role in the transmission of signal molecules between different cells. Epithelial cells are the first-line defense system against various inhaled allergens causing chronic respiratory diseases (CRD), such as asthma and chronic obstructive pulmonary disease (COPD). It's noted that increasing literature shows the exosomes derived from epithelial cells are involved in the pathogenesis of CRD. Moreover, the correlations between exosome cargo and the disease phenotypes show a high potential of using exosomes as biomarkers of CRD. In this review, we mainly focus on the physiological functions of epithelial-derived exosomes and illustrate the involved mechanism of epithelial-derived exosomes in common CRD.

• Authors: Yu Yang, Lin Yuan, Xizi Du, Kai Zhou, Ling Qin, Leyuan Wang, Ming Yang, Mengping Wu, Zhiyuan Zheng, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Chi Liu
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 143 Pg. 112189 (Nov 2021) ISSN: 1950-6007 [Electronic] France
• PMID: 34560534 (Publication Type: Journal Article, Review)
• Copyright: Crown Copyright © 2021. Published by Elsevier Masson SAS. All rights reserved.

Chemical References

• Biomarkers

Topics

• Airway Remodeling
• Animals
• Biomarkers (metabolism)
• Epithelial Cells (metabolism)
• Exosomes (metabolism, transplantation)
• Humans
• Predictive Value of Tests
• Prognosis
• Respiratory System (metabolism, physiopathology)
• Respiratory Tract Diseases (diagnosis, metabolism, physiopathology, therapy)
• Signal Transduction