Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles.

Abstract

OBJECTIVE:

 To establish a relationship between serum progesterone values on the day of frozen blastocyst transfer in hormone-replaced cycles with the probability of pregnancy, miscarriage or delivery.

METHODS:

 This was an ambispective observational study including all frozen-thawed embryo transfer cycles performed at our department following in vitro fecundation from May 2018 to June 2019. The outcomes evaluated were β human chorionic gonadotropin (β-hCG)-positive pregnancy and delivery. Groups were compared according to the level of serum progesterone on the day of embryo transfer: the 1st quartile of progesterone was compared against the other quartiles and then the 2nd and 3rd quartiles against the 4th quartile.

RESULTS:

 A total of 140 transfers were included in the analysis: 87 with β-HCG > 10 IU/L (62%), of which 50 (36%) delivered and 37 had a miscarriage (42%). Women with lower progesterone levels (< 10.7ng/mL) had a trend toward higher β-HCG-positive (72 versus 59%; p > 0.05), lower delivery (26 versus 39%; p > 0.05) and higher miscarriage rates (64 versus 33%; p < 0.01). Comparing the middle quartiles (P25-50) with those above percentiles 75, the rate of pregnancy was similar (60 versus 57%; p > 0.05), although there was a trend toward a higher number of deliveries (43 versus 31%; p > 0.05) and a lower number of miscarriages (28 versus 45%; p > 0.05). These differences were not statistically significant.

CONCLUSION:

 There were no differences in pregnancy and delivery rates related with the progesterone level when measured in the transfer day. The miscarriage rate was higher in the 1st quartile group.

• Authors: José Metello, Claudia Tomás, Pedro Ferreira, Iris Bravo, MaryJo Branquinho, Samuel Santos-Ribeiro
• Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (Rev Bras Ginecol Obstet) Vol. 43 Issue 8 Pg. 608-615 (Aug 2021) ISSN: 1806-9339 [Electronic] Brazil
• Vernacular Title: Impacto da progesterona plasmática no dia da transferência de embriões congelados em ciclos induzidos por hormônios.
• PMID: 34547795 (Publication Type: Journal Article, Observational Study)
• Copyright: Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Chemical References

• Chorionic Gonadotropin, beta Subunit, Human
• Progesterone

Topics

• Chorionic Gonadotropin, beta Subunit, Human
• Embryo Transfer
• Female
• Fertilization in Vitro
• Humans
• Pregnancy
• Pregnancy Rate
• Progesterone
• Retrospective Studies