Structural Perspectives and Advancement of SGLT2 Inhibitors for the Treatment of Type 2 Diabetes.

Abstract

Diabetes mellitus is an ailment that affects a large number of individuals worldwide and its pervasiveness has been predicted to increase later on. Every year, billions of dollars are spent globally on diabetes-related health care practices. Contemporary hyperglycemic therapies to rationalize Type 2 Diabetes Mellitus (T2DM) mostly involve pathways that are insulin-dependent and lack effectiveness as the pancreas' β-cell function declines more significantly. Homeostasis via kidneys emerges as a new and future strategy to minimize T2DM complications. This article covers the reabsorption of glucose mechanism in the kidneys, the functional mechanism of various Sodium- Glucose Cotransporter 2 (SGLT2) inhibitors, their structure and driving profile, and a few SGLT2 inhibitors now accessible in the market as well as those in different periods of advancement. The advantages of SGLT2 inhibitors are dose-dependent glycemic regulation changes with a significant reduction both in the concentration of HbA1c and body weight clinically and statistically. A considerable number of SGLT2 inhibitors have been approved by the FDA, while a few others, still in preliminaries, have shown interesting effects.

• Authors: Shivani Sharma, Amit Mittal, Shubham Kumar, Anu Mittal
• Journal: Current diabetes reviews (Curr Diabetes Rev) Vol. 18 Issue 6 Pg. e170921196601 ( 2022) ISSN: 1875-6417 [Electronic] United Arab Emirates
• PMID: 34538233 (Publication Type: Journal Article)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Benzhydryl Compounds
• Glucosides
• Hypoglycemic Agents
• Sodium-Glucose Transporter 2 Inhibitors
• Glucose

Topics

• Benzhydryl Compounds
• Diabetes Mellitus, Type 2 (complications)
• Glucose (metabolism)
• Glucosides
• Humans
• Hypoglycemic Agents (pharmacology, therapeutic use)
• Sodium-Glucose Transporter 2 Inhibitors (therapeutic use)