Extracellular Vesicle-Shuttling MicroRNAs Regulate the Development of Inflammatory Lung Responses.

Abstract

MicroRNAs are small single-stranded, non-coding RNAs which have a known role in post-transcriptional regulation of gene expression. Recent studies have reported that extracellular vesicles are capable of specific delivery of miRNAs to a target cell or tissue from a host cell. MiRNAs are generated by host cells, selectively packaged into EVs, and then delivered to nearby target cells with full functionality. After delivery to the target cells, these EV-packaged miRNAs regulate the translation of their target genes. Thus, EV transported miRNAs have become a newly understood method for intercellular communication. In this review, we summarize the novel findings of EV-miRNA transfer in acute lung injury, chronic obstructive pulmonary disease, bronchopulmonary dysplasia, asthma, and idiopathic pulmonary fibrosis.

• Authors: Jonathan M Carnino, Kareemah Ni, Yang Jin
• Journal: Annals of pulmonary and critical care medicine (Ann Pulm Crit Care Med) Vol. 1 Issue 2 Pg. 1-4 (Oct 2018) ISSN: 2641-5755 [Electronic] United States
• PMID: 34527952 (Publication Type: Journal Article)