Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug.

Abstract

A novel tumor-targeted glutathione responsive Glycosylated-Camptothecin nanosupramolecular prodrug (CPT-GL NSp) was designed and fabricated via a disulfide bond. The effects of glycoligand with different polarities on solubility, self-assembly, stability, cellular uptake, and glutathione responsive cleaving were explored, and an optimal glycosylated ligand was selected for nanosupramolecular prodrug. It has been found that CPT-GL NSp exhibited higher drug loading than traditional nanoparticles. Among of which maltose modified NSp had the strongest anti-tumor effects than that of glucose and maltotriose. CPT-SS-Maltose had a similar anti-tumor ability to Irinotecan (IR), but the superior performance in solubility, hemolysis, and uptake of HepG2 cells.

• Authors: Wenhua Li, Zhong Chen, Xiaoying Liu, Mingming Lian, Haisheng Peng, Changmei Zhang
• Journal: Drug delivery (Drug Deliv) Vol. 28 Issue 1 Pg. 1903-1914 (Dec 2021) ISSN: 1521-0464 [Electronic] England
• PMID: 34519602 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drug Carriers
• Prodrugs
• Trisaccharides
• maltotriose
• Glutathione
• Glucose
• Camptothecin

Topics

• Antineoplastic Agents, Phytogenic (administration & dosage, chemistry, pharmacology)
• Camptothecin (administration & dosage, chemistry, pharmacology)
• Cell Cycle (drug effects)
• Chemistry, Pharmaceutical (methods)
• Drug Carriers (chemistry)
• Drug Liberation
• Drug Stability
• Glucose (chemistry)
• Glutathione (chemistry)
• Hemolysis (drug effects)
• Hep G2 Cells
• Humans
• Nanoparticles (chemistry)
• Prodrugs
• Trisaccharides (chemistry)