Abstract | BACKGROUND: METHODS: This study aimed at investigating the effect of glipizide combined with ANP on breast cancer. Glipizide, ANP, or glipizide combined with ANP was intraperitoneally injected into MMTV-PyMT mice. To explore whether the anticancer efficacy of glipizide combined with ANP was correlated with angiogenesis, a tube formation assay was performed. RESULTS: CONCLUSION: These results demonstrate that glipizide combined with ANP has a greater potential than glipizide alone to be repurposed as an effective agent for the treatment of breast cancer by targeting tumor-induced angiogenesis.
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Authors | Guanquan Mao, Shuting Zheng, Jinlian Li, Xiaohua Liu, Qin Zhou, Jinghua Cao, Qianqian Zhang, Lingyun Zheng, Lijing Wang, Cuiling Qi |
Journal | Anti-cancer agents in medicinal chemistry
(Anticancer Agents Med Chem)
Vol. 22
Issue 9
Pg. 1735-1741
( 2022)
ISSN: 1875-5992 [Electronic] Netherlands |
PMID | 34515012
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Angiogenesis Inhibitors
- Vascular Endothelial Growth Factor A
- Atrial Natriuretic Factor
- Vascular Endothelial Growth Factor Receptor-2
- Glipizide
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Topics |
- Angiogenesis Inhibitors
(pharmacology, therapeutic use)
- Animals
- Atrial Natriuretic Factor
(pharmacology, therapeutic use)
- Breast Neoplasms
(drug therapy, pathology)
- Cell Movement
- Cell Proliferation
- Diabetes Mellitus, Type 2
(drug therapy)
- Female
- Glipizide
(pharmacology, therapeutic use)
- Human Umbilical Vein Endothelial Cells
- Humans
- Mice
- Neovascularization, Pathologic
(drug therapy, pathology)
- Vascular Endothelial Growth Factor A
(metabolism)
- Vascular Endothelial Growth Factor Receptor-2
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