Abstract | BACKGROUND: METHODS: A nested case-control study was conducted among patients diagnosed with AF, whose information was acquired from the prospective China Atrial Fibrillation Registry (China-AF), from August 2011 to December 2018. RESULTS: This study compared patients with stroke group (n = 145) with a matched control group (n = 577). Demographic data were similar except for body mass index (BMI), diastolic blood pressure (DBP) which were higher, and new oral anticoagulant ( NOAC) treatment rate which was lower in the stroke group (all P < 0.05). Baseline median [IQR] levels of including triglyceride (TG) were higher in the stroke group (21.96 [16.74, 21.52], mg/dL) than the control group (19.62 [14.76, 27.36], mg/dL) (P = 0.012), while the total cholesterol (TC), low-density lipoprotein cholesterol ( LDL-C) and high-density lipoprotein cholesterol (HDL-C) were similar between the two groups. Elevated TG and HDL-C were positively associated with ischemic stroke (OR 1.01, 95% CI 1.00-1.02, P = 0.032; OR 1.03, 95% CI 1.00-1.05, P = 0.025), after adjustment for BMI, systolic blood pressure, DBP, CHA2DS2-VASc score, HAS-BLED score, NOAC, LDL-C and HDL-C. However, NOAC (OR 0.20, 95% CI 0.05-0.84, P = 0.029) could decrease the likelihood of ischemic stroke in patients with AF. In subgroup analysis, higher TG level remained significantly associated with ischemic stroke for AF patients without a history of smoking (OR 1.26, 95% CI 1.02-1.55, P = 0.028). CONCLUSION: Higher level of TG and HDL-C were positively associated with ischemic stroke in patients with AF.
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Authors | Fei Li, Xin Du, Liu He, Chao Jiang, Shijun Xia, Changsheng Ma, Jianzeng Dong |
Journal | BMC cardiovascular disorders
(BMC Cardiovasc Disord)
Vol. 21
Issue 1
Pg. 424
(09 08 2021)
ISSN: 1471-2261 [Electronic] England |
PMID | 34496759
(Publication Type: Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Biomarkers
- Cholesterol, HDL
- Triglycerides
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Topics |
- Aged
- Aged, 80 and over
- Atrial Fibrillation
(diagnosis, epidemiology)
- Beijing
(epidemiology)
- Biomarkers
(blood)
- Case-Control Studies
- Cholesterol, HDL
(blood)
- Dyslipidemias
(blood, diagnosis, epidemiology)
- Female
- Humans
- Ischemic Stroke
(diagnosis, epidemiology)
- Male
- Middle Aged
- Prognosis
- Registries
- Risk Assessment
- Risk Factors
- Time Factors
- Triglycerides
(blood)
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