Therapeutic potential of marine peptides in glioblastoma: Mechanistic insights.

Abstract

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in humans. It is characterized by excessive cell growth and accelerated intrusion of normal brain tissue along with a poor prognosis. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, is largely ineffective, with high mortality and recurrence rates. As a result, traditional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The physiological effects of marine peptides in glioblastoma are mediated by a range of pathways, including apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability; autophagy and metabolic enzymes downregulation. Herein, we address the efficacy of marine peptides as putative safe therapeutic agents for glioblastoma coupled with detail molecular mechanisms.

• Authors: Salman Ahmed, Muhammad Mohtasheemul Hasan, Michael Aschner, Hamed Mirzaei, Waqas Alam, Syed Muhammad Mukarram Shah, Haroon Khan
• Journal: Cellular signalling (Cell Signal) Vol. 87 Pg. 110142 (11 2021) ISSN: 1873-3913 [Electronic] England
• PMID: 34487816 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Peptides

Topics

• Apoptosis
• Autophagy
• Brain Neoplasms (metabolism)
• Cell Line, Tumor
• Cell Survival
• Glioblastoma (metabolism)
• Humans
• Peptides (pharmacology, therapeutic use)