COVID-19 vaccine effectiveness among the staff of the Bologna Health Trust, Italy, December 2020-April 2021.

Abstract

BACKGROUND AND AIM:

Randomized controlled trials have shown that mRNA vaccines are highly effective in preventing SARS-CoV2 infection. We conducted a study to assess the real-world effectiveness of mRNA vaccines (Pfizer-BioNTech or Moderna) in preventing all and symptomatic SARS-CoV2 infections and COVID-19 related hospitalizations in the staff of the Bologna Health Trust (HT), Italy Methods: We followed up retrospectively 9839 staff of the Bologna HT from December 27, 2020 to April 3, 2020 and calculated the effectiveness in partially and fully vaccinated subjects by applying a multivariable Cox proportional hazard model.

RESULTS:

Vaccine effectiveness in preventing SARS-CoV2 infections is 85.5% (95%CI: 75.9-91.3) in the partially vaccinated and 84.8% (95%CI: 73.2-91.4) in the fully vaccinated. In preventing symptomatic infection effectiveness is 81.7% (95%CI: 62.7-91.0) in the partially and 87.1% (95%CI: 69.3-94.6) in the fully vaccinated. There were no COVID-19-related hospitalizations in the partially or fully vaccinated vs 15 hospitalization in the unvaccinated cohort.

CONCLUSIONS:

Our results confirm the effectiveness of mRNA vaccines in a real-world setting in Northern Italy.

• Authors: Chiara Giansante, Elisa Stivanello, Vincenza Perlangeli, Filippo Ferretti, Paolo Marzaroli, Muriel Assunta Musti, Lorenzo Pizzi, Davide Resi, Simona Saraceni, Paolo Pandolfi
• Journal: Acta bio-medica : Atenei Parmensis (Acta Biomed) Vol. 92 Issue 4 Pg. e2021270 (09 02 2021) ISSN: 2531-6745 [Electronic] Italy
• PMID: 34487060 (Publication Type: Journal Article)

Chemical References

• COVID-19 Vaccines
• RNA, Viral
• Vaccines

Topics

• COVID-19
• COVID-19 Vaccines
• Humans
• Italy
• RNA, Viral
• Retrospective Studies
• SARS-CoV-2
• Vaccines