Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury.

Abstract

Infections with neuraminidase-producing bacteria can lead to acute kidney injury (AKI). We herein report a 74-year-old woman who developed AKI in the course of Capnocytophaga infection, a neuraminidase-producing bacterium. A renal biopsy showed tubulointerstitial injury accompanied by specific binding of fluorescence-conjugated peanut lectin to the tubular epithelial cells, suggesting exposure of Thomsen-Friedenreich antigen (T-antigen) on the tubules. Although AKI is often observed in patients infected with Capnocytophaga, little is known about its etiology and associated pathology. This case suggests that tubulointerstitial injury caused by neuraminidase production and resultant T-antigen exposure is a mechanism of Capnocytophaga infection-induced AKI.

• Authors: Takahiro Uchida, Takashi Oda, Dan Inoue, Shuhei Komatsu, Tadasu Kojima, Tomohiro Tomiyasu, Noriko Yoshikawa, Muneharu Yamada
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 61 Issue 7 Pg. 1021-1026 (Apr 01 2022) ISSN: 1349-7235 [Electronic] Japan
• PMID: 34471025 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Thomsen-Friedenreich antigen

Topics

• Acute Kidney Injury (etiology)
• Aged
• Antigens, Tumor-Associated, Carbohydrate
• Capnocytophaga
• Female
• Humans
• Kidney Tubules