Trends in hospitalizations of newborns with hyperbilirubinemia and kernicterus in United States: an epidemiological study.

Abstract

BACKGROUND:

Hyperbilirubinemia is one of the most common diagnosis in newborn nurseries in United States. Universal pre-discharge bilirubin screening decreased the incidence of extreme hyperbilirubinemia and risk of kernicterus.

OBJECTIVES:

We sought to assess temporal population trends of hyperbilirubinemia, kernicterus and usage of phototherapy, intravenous immunoglobulin (IVIG), and exchange transfusion.

DESIGN/METHODS:

Data from Healthcare Cost and Utilization Project (HCUP)-the Kids' Inpatient Database (KID) obtained for years 1997-2012. All neonatal discharges with ICD-9 codes for neonatal jaundice (774.2, 774.6), kernicterus (773.4, 774.7) and procedure codes for phototherapy (99.83), IVIG infusion (99.14), exchange transfusion (99.01) were extracted. We compared the trends of diagnosis of hyperbilirubinemia, kernicterus, use of phototherapy, IVIG, and exchange transfusion.

RESULTS:

During the study period, the proportion of infants diagnosed with hyperbilirubinemia increased by 65% (9.4% vs. 15.5%; p<.001) in term infants and 34.5% (33.5% vs. 45%; p<.001) in preterm infants, respectively. Rate of kernicterus discharges significantly reduced from 7 to 1.9 per 100,000 newborns. Overall, the number of exchange transfusions has decreased by 67% during study period while phototherapy and IVIG use increased by 83% and 170%, respectively.

CONCLUSIONS:

In last two decades, there was a significant decrease in neonatal discharges with a history of exchange transfusion or with a diagnosis of kernicterus. However, there was a significant increase in number of neonates discharged home with a history of phototherapy during birth hospitalization and decreased number of exchange transfusions were observed during the study period. Incremental implementation of universal predischarge bilirubin screening and treatments based on 2004 AAP recommended risk-based strategies might have contributed to timely interventions in infants with significant hyperbilirubinemia.

• Authors: Ramesh Vidavalur, Srisatish Devapatla
• Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 35 Issue 25 Pg. 7701-7706 (Dec 2022) ISSN: 1476-4954 [Electronic] England
• PMID: 34470114 (Publication Type: Journal Article)

Chemical References

• Immunoglobulins, Intravenous
• Bilirubin

Topics

• Infant, Newborn
• United States (epidemiology)
• Humans
• Kernicterus (epidemiology, therapy)
• Immunoglobulins, Intravenous (therapeutic use)
• Infant, Premature
• Hyperbilirubinemia (epidemiology, therapy, complications)
• Exchange Transfusion, Whole Blood (adverse effects)
• Bilirubin
• Hospitalization
• Phototherapy (adverse effects)
• Epidemiologic Studies
• Hyperbilirubinemia, Neonatal (epidemiology, therapy)