Although the connection between
heat shock protein 70 (HSP70) and vestibular
migraine is not clear, HSP70 is neuroprotective in other scenarios. This study aimed to investigate the potential of exogenous HSP70 for treating
migraine-like symptoms in a mouse model of
nitroglycerin (NTG)-induced
migraine. HSP70 levels were assessed in patients with vestibular
migraine and healthy individuals by ELISA.
Migraine was induced in mice by NTG, and HSP70 expression was examined in the trigeminal nucleus caudalis (TNC) tissue of mice treated with NTG and NTG together with exogenous HSP70. The effects of exogenous HSP70 on
migraine-like symptoms were assessed through behavioral assays. Finally, the impact of HSP70 on oxidative stress and NF-κB signaling in mice with
migraine was investigated. Serum HSP70 in patients with vestibular
migraine was significantly lower than that of healthy individuals. NTG administration significantly suppressed HSP70 expression in mouse TNC tissue, which was reversed by exogenous HSP70. HSP70 alleviated NTG-induced mechanical
hypersensitivity, light aversion, and anxiety-like behavior. Finally, exogenous HSP70 suppressed NTG-induced oxidative stress and NF-κB signaling. Our study suggests that exogenous HSP70 may be a potential
therapy for alleviating
migraine symptoms and our promising finding warrants further investigation of HSP70 for clinical application.NEW & NOTEWORTHY The study suggests that exogenous HSP70 may be a potential
therapy for alleviating
migraine symptoms and our promising finding warrants further investigation of HSP70 for clinical application.