IgD multiple myeloma with central nervous system involvement: A case report and literature review.

Abstract

Central nervous system (CNS) involvement is a rare manifestation of multiple myeloma (MM) and the optimal management strategies have yet to be determined. The aim of the present study was to describe the case of a 47-year-old male patient with immunoglobulin D-λ MM who presented with multiple extramedullary infiltrations at diagnosis. This patient achieved stringent complete response after 9 cycles of treatment with bortezomib, lenalidomide and dexamethasone, and then received lenalidomide as maintenance therapy. CNS involvement and extramedullary relapse developed 3 months after the last chemotherapy cycle. Despite receiving a second-line treatment protocol, the patient succumbed to the disease within 1 month after recurrence. The characteristics and treatment options for CNS MM are discussed in this case report.

• Authors: Yi Chen, Yanyan Qiu, Haiying Fu, Jing Li, Lushan Chen, Siqin Liao, Tingbo Liu
• Journal: Molecular and clinical oncology (Mol Clin Oncol) Vol. 15 Issue 4 Pg. 198 (Oct 2021) ISSN: 2049-9469 [Electronic] England
• PMID: 34462654 (Publication Type: Journal Article)
• Copyright: Copyright: © Chen et al.