Similar Results in Liver Transplantation From Controlled Donation After Circulatory Death Donors With Normothermic Regional Perfusion and Donation After Brain Death Donors: A Case-Matched Single-Center Study.

Abstract	Although good results have been reported with the use of normothermic regional perfusion (NRP) in controlled donation after circulatory death (cDCD) liver transplantation (LT), there is a lack of evidence to demonstrate similar results to donation after brain death (DBD). We present a single-center retrospective case-matched (1:2) study including 100 NRP cDCD LTs and 200 DBD LTs and a median follow-up of 36 months. Matching was done according to donor age, recipient Model for End-Stage Liver Disease score, and cold ischemia time. The following perioperative results were similar in both groups: alanine transaminase peaks of 909 U/L in the DBD group and 836 U/L in the cDCD group and early allograft disfunction percentages of 21% and 19.2%, respectively. The 1-year and 3-year overall graft survival for cDCD was 99% and 93%, respectively, versus 92% and 87%, respectively, for DBD (P = 0.04). Of note, no cases of primary nonfunction or ischemic-type biliary lesion were observed among the cDCD grafts. Our results confirm that NRP cDCD LT meets the same outcomes as those obtained with DBD LT and provides evidence to support the idea that cDCD donors per se should no longer be considered as "marginal donors" when recovered with NRP.
Authors	Patricia Ruiz, Andres Valdivieso, Ibone Palomares, Mikel Prieto, Alberto Ventoso, Patricia Salvador, Maria Senosiain, Jose Ramon Fernandez, Milagros Testillano, Francisco Javier Bustamante, Mikel Gastaca
Journal	Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (Liver Transpl) Vol. 27 Issue 12 Pg. 1747-1757 (12 2021) ISSN: 1527-6473 [Electronic] United States
PMID	34455694 (Publication Type: Journal Article)
Copyright	Copyright © 2021 by the American Association for the Study of Liver Diseases.
Topics	Brain Death Death End Stage Liver Disease (surgery) Graft Survival Humans Liver Transplantation (methods) Organ Preservation (methods) Perfusion (methods) Retrospective Studies Severity of Illness Index Tissue Donors

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