Abstract | BACKGROUND: METHODS: RESULTS: Partial correlation analysis controlled for BMI and age showed a significant correlation between ImP and diastolic blood pressure (rs = 0.285, p = 0.004) and a borderline significance with systolic blood pressure (rs = 0.187, p = 0.060); however, systolic and diastolic blood pressure did not correlate with ImP precursor histidine (rs = 0.063, p = 0.526 and r = -0.038, p = 0.712, respectively). We did not find a correlation between ImP with LDL-cholesterol or HDL-cholesterol (rs = -0.181, p = 0.064 and rs = 0.060, p = 0.546, respectively). Furthermore, there was no association between plasma ImP concentrations and Rd and EGP suppression. CONCLUSION: In this cohort with overweight/obese subjects without T2D, plasma ImP concentrations were positively correlated with diastolic blood pressure but not with insulin-sensitivity.
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Authors | Jamie van Son, Mireille J Serlie, Marcus Ståhlman, Fredrik Bäckhed, Max Nieuwdorp, Judith Aron-Wisnewsky |
Journal | Nutrients
(Nutrients)
Vol. 13
Issue 8
(Aug 06 2021)
ISSN: 2072-6643 [Electronic] Switzerland |
PMID | 34444866
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Imidazoles
- Lipids
- 5-imidazolepropionic acid
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Topics |
- Bacteria
(metabolism)
- Biomarkers
(blood)
- Blood Pressure
- Female
- Gastrointestinal Microbiome
- Humans
- Imidazoles
(blood)
- Insulin Resistance
- Lipids
(blood)
- Male
- Middle Aged
- Obesity
(blood, microbiology, physiopathology)
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