Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion.

Abstract

Tumor cells grown in the presence of 1-O-alkyl-2-O-methylglycero-3-phosphocholine (AMG-PC) accumulated this ether lipid in their membranes. Depending on the cell type and the dose of the compound, up to 17% of the total phospholipids of the purified plasma membranes consisted of authentic AMG-PC. Extensive incorporation of the agent resulted in a decrease in plasma membrane fluidity and inhibition of tumor cell invasiveness in embryonic chick heart fragments. The extent of AMG-PC incorporation and fluidity change was not strictly correlated with the degree to which tumor cell invasion was inhibited.

• Authors: W J van Blitterswijk, H Hilkmann, G A Storme
• Journal: Lipids (Lipids) Vol. 22 Issue 11 Pg. 820-3 (Nov 1987) ISSN: 0024-4201 [Print] United States
• PMID: 3444372 (Publication Type: Journal Article)

Chemical References

• Glyceryl Ethers
• Phospholipid Ethers

Topics

• Animals
• Cell Line
• Glyceryl Ethers (pharmacokinetics, pharmacology)
• Membrane Fluidity (drug effects)
• Phospholipid Ethers (pharmacokinetics, pharmacology)
• Rats
• Subcellular Fractions (drug effects)
• Tumor Cells, Cultured (drug effects)
• Tumor Stem Cell Assay