Abstract | BACKGROUND/OBJECTIVES: SUBJECTS/METHODS: RESULTS: The initial (6-month) decrease in L-carnitine was significantly associated with long-term (2-year) reductions in non-HDL-Chol and LDL-Chol (p < 0.05). Also, the decrease in L-carnitine was significantly related to decreases in Chol in LDL with apoCIII (p = 0.034) and Chol in [LDL + VLDL] with apoCIII (p = 0.018). We found significant interactions between dietary fat and TMAO on changes in LDL-Chol (Pinteraction = 0.013) and Chol in [LDL + VLDL] with apoCIII (Pinteraction = 0.0048); a greater increase in TMAO was related to lesser improvements in the lipoprotein outcomes if participants consumed a high-fat compared to a low-fat diet. CONCLUSIONS: Changes in TMAO and L-carnitine induced by weight-loss diets were associated with long-term improvements in atherogenic lipoproteins containing apoCIII, implicating that these metabolic changes might be predictive of an individual's response to the dietary treatment to modify the unfavorable lipid profiles in obese patients. Dietary fat intake might modify associations of TMAO changes with long-term improvements of atherogenic cholesterol metabolism in overweight and obese adults. CLINICALTRIALS. GOV IDENTIFIER: NCT00072995.
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Authors | Yoriko Heianza, Tao Zhou, Hua He, Joseph A DiDonato, George A Bray, Frank M Sacks, Lu Qi |
Journal | International journal of obesity (2005)
(Int J Obes (Lond))
Vol. 45
Issue 12
Pg. 2600-2607
(12 2021)
ISSN: 1476-5497 [Electronic] England |
PMID | 34426648
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer Nature Limited. |
Topics |
- Adult
- Diet, Reducing
(methods, standards, statistics & numerical data)
- Gastrointestinal Microbiome
(physiology)
- Humans
- Male
- Middle Aged
- Overweight
(complications, physiopathology)
- Weight Loss
(physiology)
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