Antioxidant compounds from Annona crassiflora fruit peel reduce lipid levels and oxidative damage and maintain the glutathione defense in hepatic tissue of Triton WR-1339-induced hyperlipidemic mice.

Abstract

Dyslipidemia is a risk factor for the pathogenesis of several diseases, such as obesity, hypertension, atherosclerosis and cardiovascular diseases. In addition to interfering with serum concentrations of cholesterol and triglycerides, hyperlipidemia is involved in oxidative stress increase and reduction of the endogenous antioxidant defenses. The fruit peel of Annona crassiflora crude extract (CEAc) and its polyphenols-rich fraction (PFAc) were investigated against hypertriglyceridemia, hypercholesterolemia and hepatic oxidative stress in Triton WR-1339-induced hyperlipidemic mice. Lipid parameters in serum, feces and liver, as well as hepatic oxidative status, and enzymatic and non-enzymatic antioxidant defense systems were analyzed. Pre-treatment with CEAc for 12 days decreased hepatic triglycerides and total cholesterol, and similar to PFAc, increased the high-density lipoprotein level. There were reductions in lipid peroxidation and protein carbonylation, as well as restoration of the glutathione defense system and total thiol content in the liver of the hyperlipidemic mice treated with PFAc. The fruit peel of A. crassiflora, a promising natural source of bioactive molecules, showed a potential lipid-lowering action and hepatoprotective activities triggered by reduction of oxidative damage and maintenance of the enzymatic and non-enzymatic antioxidant systems impaired by the hyperlipidemic state.

• Authors: Letícia Pereira Afonso Ramos, Allisson Benatti Justino, Natália Tavernelli, André Lopes Saraiva, Rodrigo Rodrigues Franco, Adriele Vieira de Souza, Heitor Cappato Guerra Silva, Francyelle Borges Rosa de Moura, Françoise Vasconcelos Botelho, Foued Salmen Espindola
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 142 Pg. 112049 (Oct 2021) ISSN: 1950-6007 [Electronic] France
• PMID: 34426250 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Chemical References

• Antioxidants
• Hypolipidemic Agents
• Plant Extracts
• Polyphenols
• Triglycerides
• Polyethylene Glycols
• Cholesterol
• Oxidoreductases
• Glutathione
• tyloxapol

Topics

• Animals
• Annona (chemistry)
• Antioxidants (isolation & purification, pharmacology, therapeutic use)
• Cholesterol (metabolism)
• Fruit (chemistry)
• Glutathione (metabolism)
• Hyperlipidemias (chemically induced, drug therapy)
• Hypolipidemic Agents (isolation & purification, pharmacology, therapeutic use)
• Lipid Metabolism (drug effects)
• Lipid Peroxidation (drug effects)
• Liver (drug effects)
• Male
• Mice, Inbred C57BL
• Oxidative Stress (drug effects)
• Oxidoreductases (metabolism)
• Plant Extracts (isolation & purification, pharmacology, therapeutic use)
• Polyethylene Glycols (toxicity)
• Polyphenols (isolation & purification, pharmacology, therapeutic use)
• Protein Carbonylation (drug effects)
• Triglycerides (metabolism)
• Mice