Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination.

Abstract

BACKGROUND:

Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines.

METHODS:

Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine.

RESULTS:

We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI: 11.8-39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children.

CONCLUSIONS:

These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines.

• Authors: John Hansen, Michael D Decker, Edwin Lewis, Bruce Fireman, Vitali Pool, David P Greenberg, David R Johnson, Steven Black, Nicola P Klein
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 40 Issue 12 Pg. 1122-1126 (12 01 2021) ISSN: 1532-0987 [Electronic] United States
• PMID: 34420008 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

Chemical References

• Diphtheria-Tetanus-acellular Pertussis Vaccines

Topics

• Adverse Drug Reaction Reporting Systems
• Diphtheria-Tetanus-acellular Pertussis Vaccines (adverse effects)
• Female
• Humans
• Infant
• Male
• Muscle Hypotonia (etiology)
• Vaccination (adverse effects)