Clinical efficacy and safety of using calcipotriol-betamethasone compounding agent for psoriasis treatment: a systematic review and meta-analysis.

Abstract

The main objective is to evaluate clinical efficacy and safety of using calcipotriol-betamethasone compounding agent for psoriasis treatment through a systematic review and meta-analysis. We searched MEDLINE, Embase, The Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), and WanFang Data from inception till July 31, 2020. Efficacy was evaluated based on primary outcome indicators including skin lesion improvement and overall adverse reaction rate. Secondary outcome indicators included degree of life quality improvement, clinical effectiveness rate, and specific adverse reaction rates. RevMan5.3 was used to perform the meta-analysis. 22 studies finally met our inclusion criteria for the meta-analysis. The results indicated that for short-term treatment, a sequential therapy that uses calcipotriol betamethasone compounding agent and calcipotriol improves PASI score (MD = -0.94, 95% CI - 1.38 ~ - 0.49, P < 0.0001, I2 = 49%), comparing with using only calcipotriol. From a drug safety perspective, the difference in overall adverse reaction rate is not significant between the calcipotriol group and the sequential treatment group (RR = 0.50, 95% CI 0.22 ~ 1.14, P = 0.10, I2 = 33%). Calcipotriol betamethasone compounding agent may be more effective in plaque psoriasis treatment compared to use only calcipotriol, with no significant difference in adverse reaction rate between the two groups. Although the data were collected from 13 comparison groups, each group may not have sufficient data for a thorough and comprehensive analysis. Further research may be necessary for a more detailed evaluation of effectiveness of using calcipotriol betamethasone compounding agent for plaque psoriasis treatment.

• Authors: Junrong Ren, Qi Zhu, Siyao Wang, Xiaolong Li, Zhen Sun, Nan Li, Jian Feng, Haining Ding, Sitong Dong, Hongmei Wang
• Journal: Archives of dermatological research (Arch Dermatol Res) Vol. 314 Issue 7 Pg. 633-641 (Sep 2022) ISSN: 1432-069X [Electronic] Germany
• PMID: 34417633 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Dermatologic Agents
• Drug Combinations
• calcipotriene
• Betamethasone
• Calcitriol

Topics

• Betamethasone (adverse effects)
• Calcitriol (adverse effects, analogs & derivatives)
• Dermatologic Agents (adverse effects)
• Drug Combinations
• Humans
• Psoriasis (drug therapy, pathology)
• Treatment Outcome