Dual targeting single arrow: Neutrophil-targeted sialic acid-modified nanoplatform for treating comorbid tumors and rheumatoid arthritis.

Abstract

Clinically, rheumatoid arthritis (RA) is frequently accompanied by multi-system diseases. Among them, the incidence of comorbid tumors in RA is relatively high, resulting in a gradual increase in mortality; this poses a considerable challenge to clinical treatment. To date, no effective treatment plan for simultaneous tumor and RA therapy is available. Accordingly, we reported a sialic acid-modified doxorubicin hydrochloride liposome (DOX-SAL) that targets peripheral blood neutrophils (PBNs), which play an important role in tumors and RA. Furthermore, the prepared liposome induced PBN apoptosis by binding to L-selectin, which is highly expressed on the surface of PBNs activated by inflammation. This liposome, in turn, reduced the accumulation of inflammatory neutrophils at the disease site. In the first successfully established mouse model of RA comorbidity, induced by employing S180 sarcoma cells and collagen, DOX-SAL effectively inhibited tumor growth while simultaneously alleviating systemic RA symptoms without side effects. Additionally, the animals demonstrated adequate growth during the 48 days of treatment. This treatment strategy encompasses the best of both worlds, breaking the deadlock that tumors and RA cannot be effectively treated in parallel, highlighting a new concept and reference for the clinical treatment of comorbid tumors and RA.

• Authors: Xiaoxue Lai, Shuo Wang, Miao Hu, Yiming Sun, Meng Chen, Mengyang Liu, Gang Li, Yihui Deng
• Journal: International journal of pharmaceutics (Int J Pharm) Vol. 607 Pg. 121022 (Sep 25 2021) ISSN: 1873-3476 [Electronic] Netherlands
• PMID: 34416328 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Liposomes
• N-Acetylneuraminic Acid

Topics

• Animals
• Arthritis, Rheumatoid (drug therapy)
• Liposomes
• Mice
• N-Acetylneuraminic Acid
• Neoplasms (drug therapy)
• Neutrophils