Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome.

Abstract

[Figure: see text].

• Authors: Haiyan Chu, Anastasia Sacharidou, An Nguyen, Chun Li, Ken L Chambliss, Jane E Salmon, Yu-Min Shen, Julie Lo, Gustavo W Leone, Joachim Herz, David Y Hui, Denise K Marciano, Vikki M Abrahams, Bryony V Natale, Alina P Montalbano, Xue Xiao, Lin Xu, David R Natale, Philip W Shaul, Chieko Mineo
• Journal: Circulation research (Circ Res) Vol. 129 Issue 7 Pg. 735-750 (09 17 2021) ISSN: 1524-4571 [Electronic] United States
• PMID: 34404233 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• Antibodies, Antiphospholipid
• Apoptosis Regulatory Proteins
• Dab2 protein, mouse
• Hif1a protein, mouse
• Hypoxia-Inducible Factor 1, alpha Subunit
• LDL-Receptor Related Proteins
• Spag9 protein, mouse
• low density lipoprotein receptor-related protein 8
• Protein Phosphatase 2

Topics

• Adaptor Proteins, Signal Transducing (metabolism)
• Animals
• Antibodies, Antiphospholipid (blood)
• Antiphospholipid Syndrome (complications, metabolism)
• Apoptosis Regulatory Proteins (metabolism)
• Cell Line
• Female
• Humans
• Hypoxia-Inducible Factor 1, alpha Subunit (metabolism)
• LDL-Receptor Related Proteins (metabolism)
• Mice
• Mice, Inbred C57BL
• Pre-Eclampsia (etiology, metabolism)
• Pregnancy
• Protein Phosphatase 2 (metabolism)
• Trophoblasts (metabolism)