RNA-binding motif
protein 39 (RBM39), as a key factor in
tumor-targeted
mRNA and
protein expression, not only plays a vital role in
tumorigenesis, but also has broad development prospects in clinical treatment and drug research. Moreover, since RBM39 was identified as a target of
sulfonamides, it has played a key role in the emerging field of molecule drug development. Hence, it is of great significance to study the interaction between RBM39 and
tumors and the clinical application of drug-targeted
therapy. In this paper, we describe the possible multi-level regulation of RBM39, including gene transcription, protein translation, and alternative splicing. Importantly, the molecular function of RBM39 as an important
splicing factor in most common
tumors is systematically outlined. Furthermore, we briefly introduce RBM39's
tumor-targeted drug research and its clinical application, hoping to give reference significance for the molecular mechanism of RBM39 in
tumors, and provide reliable ideas for in-depth research for future therapeutic strategies.