Abstract | OBJECTIVE: METHODS: We reviewed the literature and published clinical trial data of osilodrostat use in patients with Cushing syndrome. Detailed information related to the clinical assessment of osilodrostat use, potential drug-to-drug interactions, drug initiation, dose titration, and the monitoring of drug tolerability were discussed. RESULTS: Clinical trial data demonstrated that osilodrostat, by virtue of inhibiting 11-β hydroxylase, potently and rapidly decreased the 24-hour urinary free cortisol levels and sustained these reductions, with improved glycemia, blood pressure, body weight, and quality of life as well as lessened depression. Osilodrostat may interact with certain drugs, resulting in QT prolongation, which requires careful assessment of concomitant medications and periodic monitoring using electrocardiogram, respectively. The common adverse effects include adrenal insufficiency, hypokalemia, edema, and hyperandrogenic symptoms, which can be minimized using a slower up-titration dosing regimen. CONCLUSION:
Osilodrostat is an effective, new treatment option for CD, with positive effects on cardiovascular and quality of life parameters as well as tolerable adverse effects. This article provides a review of the pharmacology of osilodrostat and offers practical recommendations on the use of osilodrostat to treat CD.
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Authors | Kevin C J Yuen |
Journal | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
(Endocr Pract)
Vol. 27
Issue 9
Pg. 956-965
(Sep 2021)
ISSN: 1530-891X [Print] United States |
PMID | 34389514
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2021 AACE. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Imidazoles
- Pyridines
- Osilodrostat
|
Topics |
- Humans
- Imidazoles
- Pituitary ACTH Hypersecretion
(drug therapy)
- Pyridines
- Quality of Life
|