Bamboo salt has
anti-allergic, anti-inflammatory,
anti-oxidant, diabetics, anti-aging, and immune-enhancing effects, which are closely related to anti-
cancer effect. The aim of this study was to investigate the anti-
cancer effects of Sambou bamboo saltTM (SBS) in
melanoma skin cancer in vivo and in vitro models. SBS-administered mice effectively reduced
tumor growth and increased survival rate compared with B16F10 cell-inoculated mice without tissue damage, hepatotoxicity, and nephrotoxicity. SBS enhanced levels of immune-enhancing mediators, such as
interferon-γ,
interleukin (IL)-2,
IL-6,
IL-12,
tumor necrosis factor-α, and
IgE in serum and
melanoma tissues. Furthermore, SBS enhanced activities of
caspases and levels of Bax and p53, whereas decreased levels of Bcl-2. This reduction was a consequence of apoptosis signaling pathway. In conclusion, these results suggest that SBS is a potential substance for
cancer therapy. SBS has the potential to be developed either as
Korean traditional medicine or as a health functional food for
cancer therapy. PRACTICAL APPLICATIONS: In these days
cancer is one of the world's largest health problems.
Bamboo salt is used as a Korean traditional food or medicine and has beneficial effect on
inflammation. We have identified Sambou bamboo saltTM (SBS) is a potential substance for
cancer therapy. These insights suggest that SBS can potentially be utilized for health functional foods for
cancer treatment as well as improve various
cancer diseases such as
melanoma skin cancer.