The inevitable
bleeding during
tumor resection greatly increases the risk of
tumor recurrence caused by
metastasis of
cancer cells with blood, and hemostasis and prevention of post-operation
tumor recurrence is still a challenge. However, a
biomaterials approach for rapid hemostasis during
tumor resection and simultaneous prevention of
tumor recurrence is rarely reported. Here, zeolitic imidazolate framework (ZIF-8) nanoparticle-enhanced multinetwork
cryogels are proposed which provide an integrated treatment regimen for rapid hemostasis through intraoperative blood trigger shape recovery and enhanced coagulation, and prevention of postoperative
cancer recurrence via sonodynamic anticancer in a
hepatocellular carcinoma model. A series of antibacterial shape memory multifunctional
cryogels are synthesized based on
glycidyl methacrylate-functionalized quaternized
chitosan (QCSG),
dopamine-modified
hyaluronic acid (HA-DA), and
hematoporphyrin monomethyl ether (HMME)-loaded
dopamine-modified ZIF-8 (ZDH). Blood loss in different
bleeding models confirms good hemostasis of ZIF-8 loading
cryogels. Besides, in vitro tests confirm that QCSG/HA-DA/ZDH (QH/ZDH)
cryogels significantly killed
cancer cells by generating
reactive oxygen species under ultrasound. Finally, significantly reduced
tumor recurrence after the resection of ectopic
hepatocellular carcinoma further confirms the good effect of QH/ZDH
cryogels in preventing recurrence by a coordinated strategy of intraoperative hemostasis and postoperative sonodynamic
therapy by pH-responsive HMME release, showing great potential in clinical application.