HCV patients are usually under substantial oxidative stress because of
viral infection. A total of 177 patients with HCV
infection and 198 age- and sex-matched healthy controls were enrolled in this study. We evaluated the urinary levels of 8-oxo-7, 8-dihydro-2'deoxyguanosine (8-oxodGuo) and 8-oxo-7, 8-dihydroguanosine (8-oxoGuo) in patients with HCV
infection and explored the factors affecting the urinary
8-oxodGuo or
8-oxoGuo levels.
Biomarkers of liver function,
cancer, and
inflammation were determined. Nonparametric correlations were used to evaluate the correlation between
8-oxoGuo or
8-oxodGuo and various laboratory biochemical indicators. Results showed that the levels of urinary
8-oxoGuo both in male and female patients with HCV
infection were significantly higher than those in healthy controls (both p < 0.0001), while the urinary
8-oxodGuo levels only in male patients with HCV
infection were significantly higher than those in healthy controls (p < 0.01). Urinary
8-oxoGuo was significantly associated with the white blood cell count,
C-reactive protein level, and
8-oxodGuo level (p = 0.016, p = 0.003, and p = 0.000, respectively). Urinary
8-oxodGuo was significantly associated with the white blood cell count and
8-oxoGuo level (p = 0.018 and p = 0.000, respectively). A regression equation of urinary
8-oxoGuo or
8-oxodGuo was also established using the
biomarkers in plasma. The results suggested that patients with a high
C-reactive protein level are likely to have high urinary
8-oxoGuo levels as well, which may be useful for assessing the level of
inflammation and oxidative stress in HCV patients.Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1961272 .