Reperfusion therapy for acute ischemic stroke in older people: An observational real-life study.

Abstract

BACKGROUND:

While randomized clinical trials have shown the benefit of thrombolysis and endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS), we aimed to describe in a real-life study the differences between older (>80 years old) and younger patients treated for AIS.

METHODS:

Thousand patients treated with thrombolysis and/or EVT were consecutively included in a prospective monocentric database (admitted from December 2015 to May 2019 in our comprehensive stroke center). Demographic data with detailed history, baseline physical examinations and treatments, laboratory and imaging data, prestroke functional status, and outcome 3 months after stroke were analyzed.

RESULTS:

Older patients (n = 357) had more baseline comorbidities and lower levels of prestroke independence (modified Rankin scale ≤2; 67.2% vs. 96.1%) and more severe strokes (median National Institute of Health Stroke Score [NIHSS] 15 vs. 12; p < 0.001) than younger patients (n = 643). There was no difference in the reperfusion treatments used or treatment timelines. In older patients, good functional status at 3 months was less common (29.7% vs. 61.3%) and mortality was higher (37.1% vs. 11.4%) than in younger patients. Younger age was independently associated with better prognosis (odds ratio [OR] 0.37, 95% confidence interval [CI]: 0.20-0.67; p = 0.001) and lower mortality (OR 4.38, 95% CI: 2.11-9.09; p < 0.001). Among older adults, features associated with good outcome at 3 months were age (OR 0.89, 95% CI: 0.81-0.97; p = 0.01), initial NIHSS (OR 0.89, 95% CI: 0.83-0.94; p < 0.0001), and absence of severe leukoaraiosis, anticoagulant treatment, and symptomatic intracerebral hemorrhage following reperfusion therapy (respectively, OR 0.42, 95% CI: 0.19-0.93; p = 0.03; OR = 0.07, 95% CI: 0.01-0.70; p = 0.02; and OR = 0.07, 95% CI: 0.01-0.61; p = 0.02).

CONCLUSION:

Although reperfusion therapy was less successful in older patients, these patients may benefit from acute recanalization despite their age. With an increasing older adult population, high-quality prospective studies are still required to better predict functional outcome and clarify the criteria that would allow better selection of appropriate treatment.

• Authors: Justine Sudre, Laura Venditti, Claire Ancelet, Olivier Chassin, Mariana Sarov, Didier Smadja, Nicolas Chausson, François Lun, Olga Laine, Emmanuelle Duron, Christiane Verny, Laurent Spelle, Alexandra Rouquette, Nicolas Legris, Christian Denier
• Journal: Journal of the American Geriatrics Society (J Am Geriatr Soc) Vol. 69 Issue 11 Pg. 3167-3176 (11 2021) ISSN: 1532-5415 [Electronic] United States
• PMID: 34374987 (Publication Type: Journal Article, Observational Study)
• Copyright: © 2021 The American Geriatrics Society.

Topics

• Age Factors
• Aged
• Aged, 80 and over
• Comorbidity
• Female
• Humans
• Ischemic Stroke (mortality, therapy)
• Male
• Middle Aged
• Prospective Studies
• Reperfusion
• Severity of Illness Index
• Thrombectomy
• Thrombolytic Therapy
• Treatment Outcome