Comparison between oxaliplatin therapy and capecitabine monotherapy for high-risk stage II - III elderly patients with colon cancer.

Abstract

PURPOSE:

45% of colon cancer patients are elderly, yet they are often deviated from standard cancer management. The MOSAIC trial favored FOLFOX over FL with superior oncologic outcomes; however, which regimen is most beneficial in elderly population remains unclear. This study aimed to compare the efficacy of oxaliplatin-added chemotherapy and capecitabine monotherapy in high-risk stage II/stage III elderly colon cancer patients.

METHODS:

Colon cancer patients ≥70 years of age who received adjuvant chemotherapy at Inje University Busan Paik Hospital between February 2009 to April 2016 were included. Patients were separated into the oxaliplatin-added group and capecitabine monotherapy group. The primary outcomes were CSS and OS.

RESULTS:

Of 74 patients, 45 received oxaliplatin-added chemotherapy and 29 received capecitabine monotherapy. There was no difference between the two groups in CSS or OS (p = 0.9670 and p = 0.6801, respectively). The N stage was significantly associated with CSS in both uni/multivariate analysis (p = 0.0565 and p = 0.0347, respectively). The oxaliplatin-added group had more stage III patients, so we performed a subgroup analysis of CSS and OS based on stage, which also showed no significant difference.

CONCLUSIONS:

Capecitabine monotherapy is an oncologically safe regimen compared to oxaliplatin-added regimens in elderly patients with high-risk stage II/stage III colon cancer.

• Authors: Jueun Park, HyungJoo Baik, Sang Hyun Kang, Sang Hyuk Seo, Kwang Hee Kim, Min Kyung Oh, Hong Sub Lee, Sang Heon Lee, Ki Hyang Kim, Min Sung An
• Journal: Asian journal of surgery (Asian J Surg) Vol. 45 Issue 1 Pg. 448-455 (Jan 2022) ISSN: 0219-3108 [Electronic] Netherlands
• PMID: 34364765 (Publication Type: Journal Article)
• Copyright: Copyright © 2021. Published by Elsevier Taiwan LLC.

Chemical References

• Oxaliplatin
• Capecitabine
• Fluorouracil

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Capecitabine (therapeutic use)
• Chemotherapy, Adjuvant
• Colonic Neoplasms (drug therapy, pathology)
• Fluorouracil (therapeutic use)
• Humans
• Neoplasm Staging
• Oxaliplatin (therapeutic use)