PTEN protein expression has role in predicting disease-free-interval in endometrioid endometrial carcinoma.

Abstract

OBJECTIVES:

To determine the significance of tumour PTEN protein expression in endometrioid endometrial carcinoma (EEC) and it is correlation with tumour characteristics.

METHODS:

A total of 30 eligible archived paraffin-embedded tissue blocks from 61 EEC cases (January 2015-December 2017) were retrieved from the Histopathology Laboratory in Universiti Kebangsaan Malaysia Medical Centre (UKMMC) following institutional ethic approval. For PTEN protein detection, immunohistochemistry (IHC) staining was performed and the data was correlated with clinicopathologic parameters.

RESULTS:

Fourteen samples (46.7%) showed positive PTEN protein expression, while 16 (53.3%) were negative. The mean age was 62.00 ± 9.51 years old, while the mean Body Mass Index (BMI) was 27.28 ± 7.16 kg/m2. There was no significant difference between age (p=0.27, 95% CI: -10.98 to 3.21) and BMI (p=0.67, 95% CI: -4.30 to 6.58) with PTEN protein expression. There were significant correlation between PTEN protein expression with myometrial invasion (p=0.010), but not with lymphovascular space invasion (p=0.743), grade (p=0.532), stage (p=0.733) and CA-125 level (p=0.47). The higher stage correlates with the presence of LVSI (p=0.002). PTEN positive associated with longer disease-free-interval (p=0.025), but not improving the overall survival (p=0.38).

CONCLUSIONS:

Positive PTEN protein expression correlates with less myometrial invasion.

• Authors: Mohamad Nasir Shafiee, Wei Keith Lim, Cheryl Poh Shwen Shi, Ira Adila Mohamed Yasin, Aina Fatini Azemi, Muhammad Luqman Zakaria, Abdul Muzhill Hannaan Abdul Hafizz, Muaatamarulain Mustangin, Nirmala Chandralega Kampan, Nor Haslinda Abd Aziz, Reena Rahayu Md Zain
• Journal: Hormone molecular biology and clinical investigation (Horm Mol Biol Clin Investig) Vol. 42 Issue 4 Pg. 403-410 (Aug 09 2021) ISSN: 1868-1891 [Electronic] Germany
• PMID: 34364315 (Publication Type: Journal Article)
• Copyright: © 2021 Walter de Gruyter GmbH, Berlin/Boston.

Chemical References

• Biomarkers, Tumor
• PTEN Phosphohydrolase
• PTEN protein, human

Topics

• Aged
• Biomarkers, Tumor
• Endometrial Neoplasms (diagnosis, genetics, metabolism, mortality)
• Female
• Gene Expression
• Humans
• Immunohistochemistry
• Malaysia
• Middle Aged
• PTEN Phosphohydrolase (genetics, metabolism)
• Prognosis