Increased serum levels of cadmium are associated with an elevated risk of cardiovascular disease in adults.

Abstract

Previous studies have determined the effects of exposure to certain heavy metals on cardiovascular disease (CVD); however, the association between cadmium exposure and CVD in adults remains unclear. The relationship between serum levels of cadmium and the risk of CVD was studied by analyzing available data from 38,223 different participants of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2016. After adjusting for all covariates, we found that higher serum cadmium concentrations were positively related to both the overall risk of CVD (odds ratio (OR): 1.45; 95% confidence interval (CI): 1.22, 1.72; p for trend <0.001) and the risks of its subtypes, including congestive heart failure, coronary heart disease, heart attack, and stroke. Elevated cadmium levels were associated with increased levels of lipids and inflammatory factors, including blood triglycerides, total cholesterol, white blood cells (WBCs), and C-reactive protein (CRP). Our study provided epidemiological evidence that cadmium may increase the risk of CVD by elevating blood lipids and inflammation.

• Authors: Siyu Ma, Jie Zhang, Cheng Xu, Min Da, Yang Xu, Yong Chen, Xuming Mo
• Journal: Environmental science and pollution research international (Environ Sci Pollut Res Int) Vol. 29 Issue 2 Pg. 1836-1844 (Jan 2022) ISSN: 1614-7499 [Electronic] Germany
• PMID: 34363163 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Metals, Heavy
• Cadmium

Topics

• Cadmium
• Cardiovascular Diseases (chemically induced, epidemiology)
• Environmental Exposure (analysis)
• Humans
• Metals, Heavy
• Nutrition Surveys
• Risk Factors