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Cisplatin chemotherapy and renal function.

Abstract
Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney toxicities. This review details those biochemical pathways and metabolic conversions that underlie the kidney toxicities. A wide range of redox events contribute to the eventual physiological consequences of drug activities.
AuthorsJie Zhang, Zhi-Wei Ye, Kenneth D Tew, Danyelle M Townsend
JournalAdvances in cancer research (Adv Cancer Res) Vol. 152 Pg. 305-327 ( 2021) ISSN: 2162-5557 [Electronic] United States
PMID34353441 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2021 Elsevier Inc. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Antioxidants
  • Glutathione
  • Cisplatin
Topics
  • Antineoplastic Agents (pharmacology)
  • Antioxidants (metabolism)
  • Cisplatin (metabolism, pharmacology)
  • Glutathione (metabolism, pharmacology)
  • Humans
  • Kidney (metabolism)
  • Neoplasms (drug therapy, metabolism)
  • Oxidative Stress

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