UniPortal thoracoscopic pneumonectomy does not compromise perioperative and long-term survival in patients with NSCLC: A retrospective, multicenter, and propensity score matching study.

Abstract

OBJECTIVES:

To compare the perioperative and oncologic outcomes following pneumonectomy performed by uniportal video-assisted thoracoscopic surgery (U-VATS) and thoracotomy in patients with centrally located non-small cell lung cancer (NSCLC).

MATERIALS AND METHODS:

Patients with NSCLC who underwent pneumonectomy at the Shanghai Pulmonary Hospital (SPH) and Sun Yat-sen University Cancer Center (SYUCC) with the U-VATS approach or open approach between 2011 and 2016 were selected. Propensity score matching (1:3) was performed to balance the baseline covariates. Overall survival (OS) rates and recurrence-free survival (RFS) rates were estimated and compared using the Kaplan-Meier method, respectively.

RESULTS:

The enrollees in the study were 579 patients in the SPH cohort, with 501 (86.5%) in the open group and 48 (13.5%) in the U-VATS group, and 271 patients in the SYUCC cohort, with 245 (90.4%) in the open group and 26 (9.6%) in the U-VATS group. After propensity score matching, morbidity rates and 30-day mortality rates were found to be similar between the U-VATS group and open group in both the SPH and SYUCC cohorts. The long-term OS rate of patients who underwent U-VATS pneumonectomy did not significantly differ compared with the patients who underwent open pneumonectomy in both cohorts (SPH, p = .900; SYUCC, p = .240). Cox regression analysis revealed that the surgical option was not a risk factor for the OS rate (SPH: hazard ratio [HR], 0.925; 95% confidence interval [CI], 0.555 to 1.542; SYUCC: HR, 1.524; 95% CI, 0.752 to 3.087).

CONCLUSION:

U-VATS can be used to safely perform pneumonectomy in patients with centrally located NSCLC without compromising the perioperative and oncologic outcomes compared with an open approach.

• Authors: Jiani Gao, Lei Zhang, Zhixin Li, Fang Wang, Lihong Qiu, Xiaomeng Dou, Chao Li, Yuming Zhu, Guowei Ma, Gening Jiang, Dong Xie, Chang Chen
• Journal: Lung cancer (Amsterdam, Netherlands) (Lung Cancer) Vol. 159 Pg. 135-144 (09 2021) ISSN: 1872-8332 [Electronic] Ireland
• PMID: 34340110 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Topics

• Carcinoma, Non-Small-Cell Lung (surgery)
• China (epidemiology)
• Humans
• Lung Neoplasms (surgery)
• Pneumonectomy
• Propensity Score
• Retrospective Studies
• Thoracic Surgery, Video-Assisted
• Thoracotomy
• Treatment Outcome