Abstract | BACKGROUND: OBJECTIVE: METHODS: We retrospectively collected data from 16 worldwide centers. Overall survival and progression-free survival were analyzed using Kaplan-Meier curves. Cox proportional models were used for univariate and multivariate analyses. RESULTS: We collected data from 66 patients with metastatic sarcomatoid renal cell carcinoma receiving cabozantinib as second-line (51%) or third-line (49%) therapy. The median progression-free survival from the start of cabozantinib was 7.59 months (95% confidence interval [CI] 5.75-17.49) and was longer in male patients (8.81 vs 5.95 months, p = 0.042) and in patients without bone metastases (7.59 vs 5.11 months, p = 0.010); the median overall survival was 9.11 months (95% CI 7.13-23.80). At the multivariate analysis, female sex (hazard ratio = 1.81; 95% CI 1.02-3.37, p = 0.046), bone metastases (hazard ratio = 2.62; 95% CI 1.34-5.10, p = 0.005), and International Metastatic Renal Cell Carcinoma Database Consortium criteria (hazard ratio = 3.04; 95% CI 1.54-5.99, p = 0.001) were significant predictors of worse overall survival. CONCLUSIONS:
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Authors | Matteo Santoni, Francesco Massari, Enrique Grande, Giuseppe Procopio, Marc R Matrana, Mimma Rizzo, Ugo De Giorgi, Umberto Basso, Michele Milella, Roberto Iacovelli, Gaetano Aurilio, Lorena Incorvaia, Sebastiano Buti, Orazio Caffo, Giuseppe Fornarini, Francesco Carrozza, Veronica Mollica, Alessandro Rizzo, Fady Farag, Javier Molina-Cerrillo, Nicola Battelli |
Journal | Targeted oncology
(Target Oncol)
Vol. 16
Issue 5
Pg. 625-632
(09 2021)
ISSN: 1776-260X [Electronic] France |
PMID | 34338966
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG. |
Chemical References |
- Anilides
- Pyridines
- cabozantinib
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Topics |
- Anilides
- Carcinoma, Renal Cell
(drug therapy)
- Cell Differentiation
- Female
- Humans
- Kidney Neoplasms
(drug therapy)
- Male
- Pyridines
- Retrospective Studies
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