Pouchitis: Clinical Features, Diagnosis, and Treatment.

Abstract

Procto-colectomy with an ileal pouch anal anastomosis is the procedure of choice for ulcerative colitis patients that require colectomy. Pouchitis is a non-specific inflammation of the ileal reservoir, and the most common, inflammatory and long-term, complication after pouch surgery for ulcerative colitis. The aetiology is still unknown, but many risk factors have been individuated. Pouchitis can be classified based on aetiology, duration, clinical course, and response to antibiotic therapy. Accurate diagnosis and classification is the key factor for an adequate management, and exclusion of secondary causes of pouchitis is pivotal. Most of the patients consistently respond to antibiotic therapy, but management of the subgroup of patients with chronic-antibiotic-resistant-pouchitis is still challenging, being this entity one of the major causes of pouch failure.

• Authors: Paolo Gionchetti, Carlo Calabrese, Silvio Laureti, Gilberto Poggioli, Fernando Rizzello
• Journal: International journal of general medicine (Int J Gen Med) Vol. 14 Pg. 3871-3879 ( 2021) ISSN: 1178-7074 [Print] New Zealand
• PMID: 34335051 (Publication Type: Journal Article, Review)
• Copyright: © 2021 Gionchetti et al.