Abstract | OBJECTIVE: METHOD: .A triangular approach integrating both anchor-based and distributive methods was used to identify meaningful change on the patient-reported Quick Inventory for Depressive Symptoms Self-Report 16-Item (QIDS-SR16) as associated with the Patient Global Impression - Severity (PGI-S). Both the QIDS-SR16 and the PGI-S are self-report measures, and were collected at five timepoints (timepoints were approximately 2-7 days apart). RESULTS: .A total of 297 adults with treatment-resistant depression (TRD) as part of either DSM-5-defined MDD or BD were included. The MCT for the QIDS-SR16 revealed that a mean improvement of 3.38 points from baseline was comparable to a 1-point improvement on the PGI-S. Together with an examination of the probability density function, a 3.5-point change is a reasonable MCT (i.e., 1-point PGI-S improvement) for the QIDS-SR16. A 2-point symptomatic improvement on the QIDS-SR16 was associated with no change on the PGI-S. CONCLUSION: .A 3.5-point reduction in the QIDS-SR16 represents a MCT based on the PGI-S for adults with treatment-resistant MDD or BD receiving intravenous ketamine treatment at a community-based mood disorders center. These findings are limited by the post-hoc nature of this analysis and open-label case-series design. Measurement-based care decisions by patients, providers and clinicians, as well as cost/reimbursement decisions should include consideration of meaningful change along with conventional objective outcomes.
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Authors | Roger S McIntyre, Orly Lipsitz, Leanna M W Lui, Nelson B Rodrigues, Hartej Gill, Flora Nasri, Rui Ling, Kayla M Teopiz, Roger C Ho, Mehala Subramaniapillai, Kevin Kratiuk, Rodrigo B Mansur, Brett D M Jones, Yena Lee, Joshua D Rosenblat |
Journal | Journal of affective disorders
(J Affect Disord)
Vol. 294
Pg. 592-596
(11 01 2021)
ISSN: 1573-2517 [Electronic] Netherlands |
PMID | 34332360
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021. Published by Elsevier B.V. |
Chemical References |
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Topics |
- Adult
- Bipolar Disorder
(drug therapy)
- Depressive Disorder, Major
(drug therapy)
- Depressive Disorder, Treatment-Resistant
(drug therapy)
- Humans
- Ketamine
(therapeutic use)
- Psychiatric Status Rating Scales
- Self Report
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