Abstract | OBJECTIVES: Uncertainty remains about the association of potassium (K) intake and sleepiness. Therefore, we aimed to explore the relationship between K excretion using 24-h urine samples and excessive daytime sleepiness (EDS) in the general population. METHODS: In a cross-sectional study, we used multi-stage proportional random sampling to obtain a study sample aged ≥ 18 years from Emin, China between March and June 2019. We collected timed 24-h urine specimens and conducted EDS assessments using the Epworth Sleepiness Scale (ESS) questionnaire. Subjects were divided into two groups by the median of 24-h urinary potassium (24-h UK). EDS was defined as ESS score ≥ 10. Multi-variable linear regression was used to examine the association between the 24-h UK and the odds of prevalent EDS. We performed a sensitivity analysis by excluding subjects under anti-hypertensive treatment and those with sleep disordered breathing by the NoSAS scale. RESULTS: A total of 470 participants with complete 24-h urine samples and ESS data (62% women, mean age 49.6 years, mean ESS score of 9.0 ± 5.2) were enrolled. The mean ESS score was significantly lower in the upper half of 24-h UK group than in the lower half (9.5 ± 5.3 vs 8.5 ± 5.1, P = 0.044), and accordingly, prevalent EDS was significantly greater in the lower half than in the higher half (49% vs 40%, P = 0.039). In further improving the propensity matching score, the results remained consistent with the overall results. In multiple linear regression, 24-h UK was negatively correlated with ESS score (β = - 0.180 (- 0.276, - 0.085), < 0.001). Sensitivity analysis demonstrated augmented results in those without anti-hypertensive treatment. CONCLUSION: Lower potassium intake, as suggested by lower UK excretion, may be implicated in the presence of EDS in the general population.
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Authors | Reyila Abudoureyimu, Mulalibieke Heizhati, Lin Wang, Mei Li, Delian Zhang, Zhongrong Wang, Zhikang Yang, Jing Hong, Nanfang Li |
Journal | Sleep & breathing = Schlaf & Atmung
(Sleep Breath)
Vol. 26
Issue 2
Pg. 733-741
(06 2022)
ISSN: 1522-1709 [Electronic] Germany |
PMID | 34331198
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG. |
Chemical References |
- Antihypertensive Agents
- Potassium
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Topics |
- Antihypertensive Agents
- Cross-Sectional Studies
- Disorders of Excessive Somnolence
(diagnosis, epidemiology)
- Female
- Humans
- Male
- Middle Aged
- Potassium
- Sleepiness
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