Abstract | OBJECTIVE: METHODS: First, NfL and pNfH were measured in 39 paired cerebrospinal fluid (CSF) and plasma samples of FAS and primary psychiatric disorders ( PPD) patients, considered as controls. Secondly, additional plasma samples were included to examine a larger cohort of 81 samples composed of symptomatic FAS and PPD patients, presymptomatic and non-carrier relatives individuals. The measures were performed using Simoa technology. RESULTS: There was a positive correlation between CSF and plasma values for NfL (p < 0.0001) and for pNfH (p = 0.0036). NfL values were higher for all phenotypes of symptomatic FAS patients compared to PPD patients (p = 0.0016 in CSF; p = 0.0003 in plasma). On the contrary, pNfH values were solely increased in FAS patients exhibiting motor impairment. Unlike symptomatic FAS patients, presymptomatic cases had comparable concentrations with non-carrier individuals. CONCLUSION: NfL, but not pNfH, appeared to be useful in a context of differential diagnosis between FTD and psychiatric patients. Nevertheless, pNfH seem more specific for the diagnosis and follow-up of motor impairments. In each specific indication, measures in CSF and plasma will provide identical interpretations.
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Authors | Jean Escal, Anthony Fourier, Maité Formaglio, Luc Zimmer, Emilien Bernard, Hélène Mollion, Muriel Bost, Mathieu Herrmann, Elisabeth Ollagnon-Roman, Isabelle Quadrio, Jean-Michel Dorey |
Journal | Journal of neurology
(J Neurol)
Vol. 269
Issue 3
Pg. 1522-1529
(Mar 2022)
ISSN: 1432-1459 [Electronic] Germany |
PMID | 34313819
(Publication Type: Journal Article)
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Copyright | © 2021. Springer-Verlag GmbH Germany, part of Springer Nature. |
Chemical References |
- Biomarkers
- Neurofilament Proteins
|
Topics |
- Amyotrophic Lateral Sclerosis
(genetics)
- Biomarkers
- Cohort Studies
- Diagnosis, Differential
- Frontotemporal Dementia
(diagnosis)
- Humans
- Neurofilament Proteins
(cerebrospinal fluid)
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