Five-year survival and prognostic factors for oropharyngeal squamous cell carcinoma: retrospective cohort of a cancer center.

Abstract

INTRODUCTION:

Oropharyngeal cancer is characterized by high morbidity and mortality. Prognostic factors for this cancer are therefore useful to predict overall survival and may provide additional therapeutic targets.

OBJECTIVE:

To evaluate the 5-year overall survival and prognostic factors for oropharyngeal squamous cell carcinoma.

METHODS:

Retrospective cohort (2008-2018) of a cancer referral center. The population of the study was a hospital-based cohort consisting of patients diagnosed with oropharyngeal cancer who underwent surgery and/or adjuvant therapy (radio- and/or chemotherapy).

RESULTS:

A total of 253 patients with oropharyngeal squamous cell carcinoma were analyzed. The mean age was 59.8 ± 11.9 years and there was a male predominance (81.8%). Smoking and alcohol consumption were found in 88.0% and 84.2% of the sample, respectively. The combination of radiotherapy and chemotherapy was the treatment modality in 42.7% of the sample, followed by surgery combined with radio- and chemotherapy in 15.8%. There were 143 deaths (events), the mean survival was 11.55 ± 9.69 months, and the 5-year overall survival rate was 1.1%. Overall survival was lower for clinical stage III/IV (p < 0.001), HPV p16-negative status (p = 0.019), and an interval > 4 weeks between diagnosis and the beginning of treatment (p < 0.007).

CONCLUSION:

Among the prognostic factors analyzed in this cohort, p16-negative status as a poor prognostic indicator and tumor stage III/IV and an interval longer than 4 weeks between diagnosis and the beginning of treatment were significantly associated with lower overall survival.

• Authors: Glória Maria de França, Weslay Rodrigues da Silva, Cristianne Kalinne Santos Medeiros, Joaquim Felipe Júnior, Edilmar de Moura Santos, Hébel Cavalcanti Galvão
• Journal: Oral and maxillofacial surgery (Oral Maxillofac Surg) Vol. 26 Issue 2 Pg. 261-269 (Jun 2022) ISSN: 1865-1569 [Electronic] Germany
• PMID: 34297231 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Topics

• Aged
• Carcinoma, Squamous Cell (surgery)
• Female
• Head and Neck Neoplasms
• Humans
• Male
• Middle Aged
• Oropharyngeal Neoplasms (pathology, surgery)
• Prognosis
• Retrospective Studies
• Squamous Cell Carcinoma of Head and Neck