Chloride intracellular channels as novel biomarkers for digestive system tumors (Review).

Abstract

Digestive system malignant tumors are common tumors, and the traditional treatment methods for these tumors include surgical resection, radiotherapy, chemotherapy, and molecularly targeted drugs. However, diagnosis remains challenging, and the early detection of postoperative recurrence is complicated. Therefore, it is necessary to explore novel biomarkers to facilitate clinical diagnosis and treatment. Accumulating evidence supports the crucial role of chloride channels in the development of multiple types of cancers. Given that chloride channels are widely expressed and involved in cell proliferation, apoptosis and cell cycle, among other processes, they may serve as a promising diagnostic and therapeutic target. Chloride intracellular channels (CLICs) are a class of chloride channels that are upregulated or downregulated in certain types of cancer. Furthermore, in certain cases, during cell cycle progression, the localization and function of the cytosolic form of the transmembrane proteins of CLICs are also altered, which may provide a key target for cancer therapy. The aim of the present review was to focus on CLICs as biomarkers for digestive system tumors.

• Authors: Hui Wang, Jiaxing An, Suyu He, Chengcheng Liao, Juan Wang, Biguang Tuo
• Journal: Molecular medicine reports (Mol Med Rep) Vol. 24 Issue 3 (Sep 2021) ISSN: 1791-3004 [Electronic] Greece
• PMID: 34278487 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers, Tumor
• CLIC1 protein, human
• Chloride Channels
• Chlorides

Topics

• Animals
• Apoptosis
• Biomarkers, Tumor
• Cell Cycle
• Cell Proliferation
• Chloride Channels (genetics, metabolism)
• Chlorides (metabolism)
• Digestive System Neoplasms (diagnosis)
• Down-Regulation
• Gastrointestinal Neoplasms (diagnosis)
• Humans
• Up-Regulation