Anti-Sandwich Structured Photo-Electronic Wound Dressing for Highly Efficient Bacterial Infection Therapy.

Abstract

Photo-electronic devices based on reactive oxygen species (ROS) generation suffer a crucial limitation in wound treatment due to their sandwich structure, which prevents the contact of ROS with wound tissue. In this work, the first anti-sandwich structured visible-light/electricity dual-responsive wound dressing is constructed for treatment of methicillin-resistant Staphylococcus aureus (MRSA), based on selenoviologen-appendant polythiophene (SeV2+ -PT)-containing polyacrylamide hydrogels. The new wound dressing is named an anti-sandwich structured photo-electronic wound dressing (PEWD). The unique structure of PEWD enables its use in synergistic electrodynamic and photodynamic therapy (EDT and PDT), providing rapid, on-demand, and sustained generation of ROS in situ via short-time light irradiation and/or wireless-controlled electrification. The PEWD possesses good flexibility, excellent biocompatibility, and fast response, as well as sustained ROS generation in a physiological environment. Animal experiments demonstrate effective ROS generation in 6 s under irradiation and electrification, inhibiting infection at an early stage, and substantially shortening the healing time of bacterial infection (to within 7 days). This proof-of-concept research holds great promise in developing new flexible PEWD, and novel strategies to improve wound treatment.

• Authors: Kun Zhou, Dongdong Chigan, Letian Xu, Chenjing Liu, Rui Ding, Guoping Li, Zixi Zhang, Dandan Pei, Ang Li, Baolin Guo, Xuzhou Yan, Gang He
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 17 Issue 33 Pg. e2101858 (08 2021) ISSN: 1613-6829 [Electronic] Germany
• PMID: 34250738 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 Wiley-VCH GmbH.

Chemical References

• Anti-Bacterial Agents
• Hydrogels

Topics

• Animals
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Bacterial Infections (drug therapy)
• Bandages
• Electronics
• Hydrogels
• Methicillin-Resistant Staphylococcus aureus