Challenge and Outcome for the Prostate Squamous Cell Carcinoma Which Developed 8 Years after Low-Dose-Rate Brachytherapy Approached by a Combined Multimodal Treatment with High-Dose-Rate Interstitial Brachytherapy, External Beam Radiation Therapy, and Chemotherapy.

Abstract

Prostate squamous cell carcinoma (pSCC) rarely develops as a secondary cancer after treatment with low-dose-rate brachytherapy (LDR-BT). There is no established effective treatment for the disease condition. Herein, we present a 78-year-old man who developed pSCC 8 years after LDR-BT. He was subsequently selected to receive a combined multimodal treatment with high-dose-rate interstitial brachytherapy (HDR-ISBT), external beam radiation therapy, and chemotherapy for his pSCC. Eleven months later, he displayed no biochemical failure nor clinical radiographic recurrence. However, MRI detected a newly developed prostatic-rectal fistula (grade 4), and a colostomy was performed to relieve pain and inflammation. To our knowledge, this is the first report to perform a combined multimodal treatment with HDR-ISBT for pSCC suspected as a secondary cancer due to LDR-BT.

• Authors: Toru Matsugasumi, Koji Masui, Kaori Yamada, Sho Watanabe, Koji Okihara, Nana Kozawa, Yasuhiro Yamada, Hideya Yamazaki, Kei Yamada, Osamu Ukimura
• Journal: Case reports in oncology (Case Rep Oncol) 2021 May-Aug Vol. 14 Issue 2 Pg. 854-860 ISSN: 1662-6575 [Print] Switzerland
• PMID: 34248551 (Publication Type: Case Reports)
• Copyright: Copyright © 2021 by S. Karger AG, Basel.